Table 1. Rate of Binding to Albumin of the Prodrug Mal-azo-Exatecan in Murine, Rat, and Human Plasma.
albumin
binding |
||
---|---|---|
time (min) | bound (%) | |
murine plasma | 2 | 95.81 ± 0.06 |
8 | 99.55 ± 0.11 | |
rat plasma | 2 | 96.77 ± 0.15 |
8 | 99.38 ± 0.12 | |
human plasma | 0.25 | 99.51 ± 0.01 |
2 | 100 ± 0.00 | |
HSA | 2 | 89.41 ± 0.05 |
8 | 99.50 ± 0.13 |