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. 2021 Dec 30;7(1):1082–1089. doi: 10.1021/acsomega.1c05671

Table 3. IC₅₀ Values of Exatecan and Mal-azo-Exatecan^a.

	exatecan				Mal-azo-Exatecan
cell lines	IC₅₀(air) (nM)	IC₅₀(N₂) (nM)	HCR	IC₅₀(air) (μM)	IC₅₀(N₂) (μM)	HCR
H460	1.47 ± 0.40	1.18 ± 0.10	1.25	49.86 ± 12.91	3.45 ± 0.32	14.43
HT29	13.24 ± 2.00	18.31 ± 6.32	0.72	95.42 ± 4.87	51.33 ± 6.65	1.86
A549	10.82 ± 0.90	11.93 ± 0.77	0.91	>100	17.22 ± 1.59	>5.88
HepG2	96.48 ± 7.02	154.86 ± 25.21	0.62	>100	32.52 ± 7.84	>3.08
MCF-7	38.34 ± 5.88	87.04 ± 4.83	0.44	>100	71.97 ± 9.33	>1.39
Mla PaCa-2	0.72 ± 0.23	0.25 ± 0.05	2.88	13.38 ± 2.10	4.99 ± 1.14	2.68

^a

Note: HCR, hypoxic cytotoxicity ratio; HCR= IC₅₀ (Air)/IC₅₀ (N₂).