Table 4. Cytotoxic Activities of 13 Quinoxalines against Four Human Cancer Cell Lines for 72 h.
| IC50 (μM) |
||||
|---|---|---|---|---|
| compounds | MCF-7 | T47D | MDA-MB-231 | A549 |
| 4aa | 16.68 ± 1.34 | 11.36±1.17 | 28.55 ± 1.85 | 26.31 ± 1.96 |
| 4ba | 15.65 ± 1.18 | 9.76 ± 1.30 | 21.45 ± 1.19 | 24.06 ±1.11 |
| 4ca | >50 | >50 | 48.84 ± 1.01 | >50 |
| 4ha | >50 | >50 | >50 | >50 |
| 4ia | 7.30 ± 1.10 | 6.25 ± 0.73 | 17.75 ±0.69 | 18.55 ±0.25 |
| 4pa | >50 | >50 | >50 | >50 |
| 4ra | >50 | >50 | >50 | >50 |
| 4ab | 10.01 ± 0.55 | 6.77 ± 0.57 | 18.21 ± 1.34 | 19.72 ± 1.28 |
| 4ac | >50 | >50 | >50 | >50 |
| 4ad | >50 | >50 | >50 | >50 |
| 4ae | >50 | >50 | >50 | >50 |
| 4af | >50 | >50 | >50 | >50 |
| 4ag | >50 | 20.52 ± 1.64 | 45.01 ± 1.57 | 44.45 ± 3.55 |
| berberinea | 14.32 ± 1.44 | 26.69 ± 2.45 | 17.96 ± 1.91 | 5.22 ± 0.44 |
a
Berberine was used as the positive control.