Table E3.

Multivariable logistic regression^∗ fitted with restricted cubic spline function for absolute eosinophil count (log10-transformed) with three knots describing nonlinear relationship between eosinophil count and outcomes measures such as hospitalization, admission to intensive care unit, and in-hospital mortality

Outcome	Estimate	SE	z Value	P
Hospitalization
X	–0.646	0.066	–9.841	<2e-16
X′	0.514	0.070	7.311	2.6e-13
Intensive care unit admission
X	–0.500	0.110	–4.524	6.1e-06
X′	0.383	0.118	3.255	0.001
Died
X	–0.784	0.130	–6.035	1.6e-09
X′	0.599	0.142	4.222	2.4e-5

Medications in the model include nonsteroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, inhaled corticosteroids, intranasal corticosteroids, and immunosuppressive therapy that includes systemic corticosteroids). Comorbidities in the model include diabetes, hypertension, coronary artery disease, heart failure and cancer (historical or current), immunosuppressive diseases, and connective tissue diseases.

^∗Adjusted for demographics, body mass index, smoking, medications, comorbidities, and the month of testing.