Table 3.

Days of each symptom after randomization, reported as median days (interquartile range), according to baseline status for each symptom (presence or absence at study entry). Number of subjects in each subgroup are indicated within parentheses below. P-values as calculated by Mann–Whitney non-parametric test. Number of subjects displaying each symptom at baseline within each treatment group can be found in Table 1

Characteristic and baseline status	Probiotic	Placebo	P-value
Fever (temperature >37.5°C)
Present at study entry (n = 215)	2 (1–5)	5 (4–8)	<0.001
Absent at study entry (n = 85)	2 (0–5)	4 (4–5)	<0.001
Cough
Present at study entry (n = 271)	10.5 (8–13)	14 (12–17)	<0.001
Absent at study entry (n = 29)	0 (0–3.3)	0 (0–0)	0.238
Headache
Present at study entry (n = 261)	7 (5–9)	12 (9–14)	<0.001
Absent at study entry (n = 39)	0 (0–0)	0 (0–0)	0.404
Shortness of breath
Present at study entry (n = 106)	2.5 (1–4)	5 (2–6.3)	<0.001
Absent at study entry (n = 194)	0 (0–0)	0 (0–0)	1.000
Body aches
Present at study entry (n = 191)	3 (2–6)	7 (5–9)	<0.001
Absent at study entry (n = 109)	0 (0–0)	0 (0–0)	0.594
Nausea
Present at study entry (n = 93)	2 (0–6)	9 (0–14)	<0.001
Absent at study entry (n = 207)	0 (0–0)	0 (0–0)	0.479
Diarrhea
Present at study entry (n = 95)	4 (0–6)	8.5 (0–13.8)	0.004
Absent at study entry (n = 205)	0 (0–0)	0 (0–0)	0.555
Loose stools
Present at study entry (n = 52)	0 (0–0)	0 (0–2)	0.026
Absent at study entry (n = 248)	0 (0–0)	0 (0–0)	0.270
Feeling of incomplete evacuation
Present at study entry (n = 57)	2 (0–3)	0 (0–3.5)	0.367
Absent at study entry (n = 243)	0 (0–0)	0 (0–0)	0.304
Abdominal pain
Present at study entry (n = 38)	4 (0–6.5)	10 (0–14)	0.031
Absent at study entry (n = 262)	0 (0–0)	0 (0–0)	0.221
Use of acetaminophen (post-hoc)
Present at study entry (n = 153)	1 (0–3)	3 (3–6)	<0.001
Absent at study entry (n = 147)	1 (0–4)	3 (3–7)	<0.001