Table I.

IBR-induced changes in expression of selected metabolic genes in MCL cells

Entrez ID	Gene Symbol	Enzyme/Protein Name	EC number	Fold Change MCL-RL	Fold Change JeKo-1	Pathway/Products Affected
	HK2	Hexokinase 2 (mito)	EC 2.7.1.1	−1.37	−1.42	Glycolysis
92483	LDHAL6B	NAD-L-lactate Dehydrogenase	EC 1.1.1.27	−1.62	*
22934	RPIA	Ribose 5-phosphate isomerase A	EC 5.3.1.6	−1.75	1.22	Pentose phosphate
790	CAD	Carbamoyl-phosphate synthase	EC 6.3.5.5	−1.51	−1.16	Glutaminolysis **
	PPAT	Phosphoribosyl amidotransferase	EC 2.4.2.14	−1.49	1.06
	GLS	Glutaminase	EC 3.5.1.2	−1.45	1.08
	MYC	MYC	−	−5.77	−1.13
	SLC1A5	Solute Carrier Family 1 Member 5		−1.55	−1.10
	SLC38A5	Solute Carrier Family 38 Member 5		−1.75	−1.02
	IDH1	Isocitrate dehydrogenase 1	EC 1.1.1.42	−1.25	1.04	Reductive carboxylation (cytosolic and mitochondrial) linked to fatty acids
	ACLY	ATP citrate lyase	EC 2.3.3.8	−1.3	−1.10
	FASN	Fatty acid synthase	EC 2.3.1.85	−1.70	−1.25
219	ALDH1B1	Aldehyde dehydrogenase (NAD) family 1(RL) or 5(JeKo-1)	EC 1.2.1.3	−1.58	−1.12	Fatty acids
	ALDH5A1		EC 1.2.1.24	1.54	1.40
1717	DHCR7	7-dehydrocholesterol reductase	EC1.3.1.21	−1.67	−1.52	Steroid, cholesterol and lipid metabolism
1588	CYP19A1	Aromatase	EC 1.14.14.14	−4.81	−1.50
1543	CYP1A1	Monooxygenase	EC1.14.14.1	−3.08	−1.33
43	ACHE	Acetylcholinesterase	EC 3.1.1.7	−3.02	−1.91	Glycerophospholipid
9388	LIPG	Triacylglycerol lipase	EC 3.1.1.3	−3.04	−1.46

^*data not shown due to very low gene expression of this LDH isoform in JeKo-1 cells

^**new enzymatic link for glutamine to glutamate inter-conversion through linked cytosolic catalysis of glutamine hydrolysis by phosphoribosyl pyrophosphate amidotransferase (PPAT)