Panel A shows the daily number of new cases of SARS-CoV-2 infection, as confirmed on polymerase-chain-reaction (PCR) assay, among 41,623 residents of Israeli long-term care facilities, along with the cumulative uptake of the BNT162b2 booster dose, from July 1 through September 11, 2021. The dashed line represents the moving average of infections. Panel B shows the changes in Covid-19 immune status among residents of long-term care facilities, according to the following categories: vaccination in process, unvaccinated and no previous Covid-19, vaccination with the second dose more than 5 months earlier, vaccination with the second dose within the past 5 months, booster vaccination 14 or more days earlier, recovered from Covid-19 and vaccinated (any number of doses), and recovered from Covid-19 and unvaccinated. Panel C shows the cumulative uptake of the BNT162b2 booster dose according to study group.