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. 2022 Jan 10;37(1):451–461. doi: 10.1080/14756366.2021.2018682

Scheme 1.

Scheme 1.

Synthesis of oleanolic acid oxime ester derivatives (3a3t). Reagents and conditions: (a) Jones reagent, acetone, 0 °C; (b) NH2OH·HCl (1.0 eq.), EtOH, NaOAc (2.0 eq.), rt, 1 h; (c) cinnamoyl chlorides and benzoyl chlorides (2.0 eq.), pyridine, DCM, 0 °C ∼ rt, overnight.