Table 3.
Clinically relevant biomarkers based on important features from clinical programs (P-1: Program-1, P-2: Program-2).
| Program | Feature name | Predicted biomarker |
|---|---|---|
| Older | ||
| Older P-1 | Ang(1 - 7) bound to Mas receptor | ACE2-Ang(1-7) ratios, ACE2 levels51,52 |
| Older P-1 | Oxygen saturation | Oxygen saturation |
| Older P-2 | Neutrophils | Neutrophil elastase myeloperoxidase53 |
| Hyperinflamed | ||
| Hyperinflamed P-1 | Oxygen saturation | Oxygen saturation |
| Hyperinflamed P-1 | Angiotensin 1-9 | Circulating Angiotensin 1-952 |
| Hyperinflamed P-1 | Free virus circulation | SARS-CoV-2 PCR cycle threshold |
| Obese, diabetic, hypertensive | ||
| Obese/Diabetic/Hypertensive P-1s | Micro thrombus in liver and cardiac vessels | D-dimer |
| Obese/Diabetic/Hypertensive P-1s | ACE2 density of upper body | ACE2 levels52 |
| Obese/Diabetic/Hypertensive P-2s | Interferon | IFN-γ levels |
| Obese/Diabetic/Hypertensive P-2s | Anti-inflammatory cytokines | IL-6, IL1β |