Figure 1. Illustration of all the optimized ligands and receptor macromolecule simultaneously. The hACE2 receptor (PDB ID: 1R4L) with its active site for complexing with the ligands (A); the drone-like structure refers to the main conformation of the pocket (A). Among the ligands serpentine (D) was the control and the others are the test ligands means – piperolactam A (B), apigenin (C), isovitexin (E), and quercetin (F).
