Table 2.
Integrated results of the mummichog and Gene Set Enrichment Analysis (GSEA) Pathway.
| Enriched Pathways | Total Size | Hits | Hits Sig. | Mummichog p values | GSEA p values | Combined p values |
|---|---|---|---|---|---|---|
| Galactose metabolism | 3 | 3 | 2 | 0.0360 | 0.0714 | 0.0179 |
| Starch and Sucrose Metabolism | 3 | 3 | 2 | 0.0360 | 0.0714 | 0.0179 |
| C21-steroid hormone biosynthesis and metabolism | 8 | 8 | 4 | 0.0066 | 0.4362 | 0.0198 |
| Bile acid biosynthesis | 11 | 11 | 4 | 0.0250 | 0.1979 | 0.0313 |
| Androgen and estrogen biosynthesis and metabolism | 3 | 3 | 2 | 0.0360 | 0.7143 | 0.1201 |
| Vitamin D3 (cholecalciferol) metabolism | 2 | 2 | 1 | 0.2215 | 0.2698 | 0.2281 |
| Lipoate metabolism | 1 | 1 | 1 | 0.1172 | 0.5192 | 0.2312 |
| Prostaglandin formation from arachidonate | 8 | 8 | 1 | 0.6421 | 0.125 | 0.2827 |
| Fatty Acid Metabolism | 4 | 4 | 1 | 0.3964 | 0.4286 | 0.4711 |
| Vitamin E metabolism | 3 | 3 | 1 | 0.3141 | 0.6857 | 0.5461 |
| Glycosphingolipid metabolism | 9 | 9 | 1 | 0.6868 | 0.3656 | 0.5981 |
| Linoleate metabolism | 7 | 7 | 1 | 0.5914 | 0.5568 | 0.6951 |
GSEA considers the overall ranks of features without using a significant cutoff. The module uses Fisher's method to combine raw p-values of mummichog and GSEA approaches.