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. 2021 Jul 21;2:685236. doi: 10.3389/froh.2021.685236

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Copyright © 2021 Shahoumi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cancer stem cell-directed therapies in HNSCC. Selected anti-CSC drugs currently under clinical investigation. Their mechanisms of actions include targeting CSC-associated surface markers and CSC-associated signaling pathways, including developmental pathways, that regulate the maintenance, and survival of CSCs.