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. 2021 Oct 4;3:707826. doi: 10.3389/fmedt.2021.707826

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Copyright © 2021 Madekurozwa, Bonneuil, Frattolin, Watson, Moore, Stevens, Moore, Mathiszig-Lee and van Batenburg-Sherwood.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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System response after the programmatic changing of all clinical parameters simultaneously (dashed vertical lines), measured using the flow analyser. Input parameters are indicated by continuous black horizontal lines, with ISO 80601-2-12:2020 measurement uncertainties indicated by grey shaded regions, with ± (4 ml + 15% of target value) for volume and ±2 cmH₂O for PEEP. (A) Inhaled volume, (B) Exhaled volume, (C) PEEP, (D) PiP, (E) Respiratory Rate, (F) I:E ratio.