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. 2020 Nov 16;2:602236. doi: 10.3389/fmedt.2020.602236

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Copyright © 2020 Pardridge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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X-gal histochemistry of Rhesus monkey organs removed 2 days after the IV administration of HIRMAb-targeted THLs encapsulated a LacZ β-galactosidase expression plasmid. The LacZ gene was driven either by the widely expressed SV40 promoter (top panel) or the eye-specific opsin promoter (bottom panel). The dose of THL encapsulated plasmid DNA for either monkey study was 70 μg plasmid DNA per monkey. Both monkeys were 6 kg female monkeys. Reproduced with permission from Pardridge (226). The replacement of the SV40 promoter with the opsin promoter eliminates LacZ gene expression in all organs, except for the eye.