Table 4.
Property | AAV | THL | References |
---|---|---|---|
Immunogenicity | High | Low | (13, 297) |
Frequency of administration | Single | Chronic | (54, 297, 303) |
Transfection of brain cells | <30% | 100% | (8, 9, 54, 256) |
Injection dose (vg/kg) | 1014 | 1012 | (10, 50) |
Size limitation of therapeutic gene | 2–4 kb | >20 kb | (9, 68) |
Chromosomal integration | At high doses | None | (11, 12, 256) |