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. 2021 Jan 25;1:603160. doi: 10.3389/froh.2020.603160

Figure 4.

Figure 4

DNA damage responses and repair pathways (redrawn from [171]). Chemo- and radiotherapy used to treat cancer can cause a variety of damage to the cellular DNA including single-strand break caused by single base damage, crosslinking of bases, mismatch of bases and double strand breaks. This causes hyperactivation of DNA repair machinery which is an important tool utilized by cancer cells to compensate for the damage. Multiple ongoing strategies to block the DNA repair and thus re-sensitize cancer cells to different therapeutic agents are summarized in this figure (red color).