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Side-by-side comparison of permeation of phenytoin across the DIB-BBB or in the rat brain. Brain penetration was calculated as a permeability as described, and 3H-phenytoin and cold phenytoin were used for in vitro and in vivo, respectively. The levels in brain and blood were measured by microanalysis; similar sampling was used in the DIV-BBB. Note the similar permeation profiles in the dynamic model compared to the rodent.
