Table 1.

Feature and specification table for VNS Therapy generator models.

	NCP M100*	NCP M101	Pulse M102™	Pulse Duo™ M102R	Demipulse® M103	Demipulse® Duo M104	AspireHC® M105	AspireSR® M106	SenTiva® M1000	SenTiva Duo™ M1000-D†
Lead receptacle	Dual-pin	Dual-pin	Single-pin	Dual-pin	Single-pin	Dual-pin	Single-pin	Single-pin	Single-pin	Dual-pin
FDA release year	1997	2000	2002	2003	2007	2007	2011	2015	2017	——–
EU certification mark year	1994	1999	2003	2003	2005	2005	2011	2014	2017	2020
HS-Ti case dimension (mm)	55 ×55 ×13.2	54 ×54 ×10.3	52 ×52 ×6.9	52 ×58.4 ×6.9	45 ×32 ×6.9	45 ×39 ×6.6	52 ×52 ×6.9	52 ×52 ×6.9	45 ×32 ×6.9	45 ×39 ×6.9
Volume (cc)	31	26	14	16	8	10	14	14	8	10
Weight (g)	55	38	25	27	16	17	25	25	16	17
Battery model	9086	9086	2075	2075	2183	2183	2075	2075	2183	2183
Rated capacity (amp-hours)	2.3	2.3	1.7	1.7	1.0	1.0	1.7	1.7	1.0	1.0
X-ray tag code	None	None	CYBX or CYBX-J-XX	CYBX or CYBX-J-XX	CYB A & VNS A	CYB A & VNS A	CYBX	CYBX	LIVN & VNS	LIVN & VNS
Time needed for magnet inhibition (s)	≥ 65	≥ 65	≥ 65	≥ 65	≥ 65	≥ 65	≥ 65	≥ 5	≥ 10	≥ 10

Feature or specification (left) with respect to VNS Therapy generator model (top). For x-ray tag code CYBX-J-XX, the “XX” signifies the year (e.g., 20 for 2020). Time needed for magnet inhibition is the time the therapy magnet needs to be held over the generator to stop stimulation.

^*Applies to M100 generators with serial numbers ≥10,000.

^†M1000-D generator is only licensed in Europe as of this review.

HC, high capacity; HS-Ti, hermetically sealed titanium; NCP, NeuroCybernetic Prosthesis; M, model; SR, sense and respond.