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. 2021 May 24;3:669763. doi: 10.3389/fmedt.2021.669763

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Copyright © 2021 Molino, Fukuda, Molino and Wallace.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Response of auditory nerve tissue to electrically-controlled NT-3 release from PPy films grown with different dopants. All polymers were grown with 2 mg/mL NT-3 in the polymerisation solution, and 7.2 C of charge were passed in the polymerisation of all films. (a–f) Show representative images of explants growing on various PPy films after electrically stimulated release of NT-3 from the PPy. (a) Explants on PPy/pTS, (b) PPy/DBS, (c) PPy/PSS, (d) PPy/PMAS (e) PPy/HA and (f) PPy/CS. (g) The average number of neurites extending from explants grown on electrically-stimulated and unstimulated films over six experiments. The error bars show one standard error of the mean of 6–60 explants on each polymer. Reproduced with permission from Thompson et al. (64).