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. 2021 May 24;3:669763. doi: 10.3389/fmedt.2021.669763

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Copyright © 2021 Molino, Fukuda, Molino and Wallace.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustration for the preparation of rGO-Ti. (B) SEM images of Ti and rGO-Ti (scale bar = 2 μm). (C) AFM images of Ti and rGO-Ti (scale bar = 500 nm). (D) Drug loading (%) on rGO-Ti. (E) Relative cell viability on Ti and rGO-Ti. Confocal microscopic images of F-actin stained preosteoblasts on (F) Ti and (G) rGO-Ti (scale bar = 25 μm). (H) Cell adhesion area determined from the region of F-actin fluorescence (*P ≤ 0.05 and ***P ≤ 0.001). Reproduced with permission from Jung et al. (130).