Table 2.
Summary of highlighted in vitro studies on cancer cell transendothelial migration.
| References | Endothelium | Migratory cell line | Extracellular matrix | Inflammatory stimulus | Flow |
|---|---|---|---|---|---|
| Chen et al. (76) | Human umbilical vein | MDA-MB-231, A-375, MA2, & 4T1 | Fibrin/Collagen I gel | 5 dyn/cm2 | |
| Cui et al. (77) | Primary human vascular | MDA-MB-231 & MCF-10A | Poly-D-lysine & fibronectin | 2.5–10 dyn/cm2 | |
| Hamilla et al. (74) | Human umbilical vein | MDA-MB-231, A375, & SW1990 | Fibronectin | 25 ng/mL TNF-α | |
| Herman et al. (78) | Human cerebral microvessel or primary rat brain | A2058, B16/F10, MDA-MB-231, & 4T1 | Rat tail collagen | ||
| Jeon et al. (79) | Human microvascular | MDA-MB-231 & MCF-10A | Collage I gel & matrigel | ||
| Li et al. (80) | Bovine aortic | Calu-1, HT-1080, Colo 205, HT-29, SW 620, SW 480, & L-132 | Matrigel | ||
| Ni et al. (81) | Human pulmonary microvessel | A459 | Collagen I gel | 0.05 dyn/cm2 | |
| Song et al. (82) | Human dermal microvascular | MDA-MB-231 | Fibronectin | 50 ng/mL TNF-α | 0.5–2.5 dyn/cm2 |
| Zervantonakis et al. (83) | Human microvessel & umbilical vein | HT1080 & MDA-MB-231 | 3D ECM (non-specific) | 2 ng/mL TNF-α |