Table 2.

Comparison of the effect of statins between the sexes on lipid parameters in the all statin initiator group.

		Unadjusted				Adjusted
Lipid parameters (mmol/L)	Groups	N	MD ± SE (%)	95% CI	P value	N	MD ± SE (%)	95% CI	P value
TC	Sex difference	543	1.13 ± 1.56	−1.93, 4.18	.470	542	−0.43 ± 1.56	−2.63, 3.48	.784∗
	Men	272	−20.99 ± 1.02	−23.15, −18.83		272	−21.80 ± 1.05	−23.85, −19.74
	Women	271	−22.11 ± 1.17	−24.40, 19.82		270	−21.37 ± 1.05	−23.43, −19.31
LDL-C	Sex difference	543	2.36 ± 2.34	−2.24, 6.97	.315	542	−0.61 ± 2.36	−5.25, 4.03	.797†
	Men	272	−26.05 ± 1.44	−28.87, −23.23		272	−27.58 ± 1.59	−30.70, −24.46
	Women	271	−28.41 ± 1.85	−32.04. −24.78		270	−26.97 ± 1.59	−30.10, −23.84
HDL-C	Sex difference	543	−2.14 ± 1.56	−5.21, 0.93	.171	542	−5.64 ± 1.67	−8.92, −2.36	.001 †
	Men	272	5.74 ± 1.03	3.32, 7.35		272	3.59 ± 1.12	1.38, 5.79
	Women	271	7.47 ± 1.18	5.17, 9.77		270	9.23 ± 1.13	7.02, 11.44
TG	Sex difference	543	−8.32 ± 4.00	−16.18, −0.45	.038	542	7.60 ± 4.24	0.73, 15.92	.073†
	Men	272	−2.56 ± 3.38	−9.19, 4.07		272	−2.89 ± 2.85	−8.48, 2.70
	Women	271	−10.87 ± 2.14	−15.06, 6.68		270	−10.49 ± 2.86	−16.10, 4.88

CI = confidence interval, DBP = diastolic blood pressure, HDL-C = high-density lipoprotein cholesterol, LDL-C = low-density lipoprotein cholesterol, MD = mean difference, N = number of participants included in the analysis, n = number of participants with the displayed lipid parameter, SBP = systolic blood pressure, SE = standard error, TC = total cholesterol, TG = triglycerides.

^∗Adjusted for age, SBP, DBP, TC, HDL-C, TG, and starting dose of simvastatin at baseline.

^†Adjusted for age, SBP, DBP, LDL-C, HDL-C, TG, and starting dose of simvastatin at baseline.