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. 2022 Jan 13;17(1):e0261939. doi: 10.1371/journal.pone.0261939

Table 4. Adverse events.

Patient 1 2 3 4 5 6 7 8
Hematologic events
Thrombocytopenia (gr) 4 3 1 3 2 3 4a 4
Leukopenia (gr) 4 4 4 4 1 4 4 4
Anemia (gr) 3 2 2 2 2 2 3b 3b
Lymphopenia (gr) 3 3 3 4 3 4 3 3
Neutropenia (gr) 4 4 4 n/a - 4 n/a n/a
Non-hematologic events
Elevated AST (gr) 2 2 1 3 3 1 2 -
Elevated ALT (gr) 1 1 - n/a n/a 2 - -
Elevated bilirubin (gr) 2 - - n/a n/a 2 - -
Fever, treatment related (gr) 2 1 - - 1 1 - -
Nausea (gr) - 1 2 - 1 1 2 -
Alopecia (gr) 1 - - - - - - 1
Other c - d - e - - f

Note: All patients received a subcutaneous injection of granulocyte-colony stimulating factor within 72h after each M-PHP procedure.

AST, aspartate transaminase; ALT, alanine transaminase; Bili, bilirubin; Gr, grade; n/a, not available; -, no adverse event.

a Treated with platelet transfusion.

b Treated with red blood cell transfusion.

c Haemorrhage groin, treated with a tight pressure dressing.

d Peripheral edema due to periprocedural overhydration, treated with diuretics.

e Lower urinary tract infection, treated with oral antibiotics.

f Aneurysma spurium, successfully treated with a thrombin injection.