Table 2.
Marker | UC-MSCs | BM-MSCs | AT-MSCs | Ref. |
---|---|---|---|---|
Secreted factors | ||||
COX-2 | ↑ | ↓ | ↓ | [45] |
bFGF (FGF-2) | ↑↑ | ↓ | ↑ | [45] |
HGF | ↑↑ | ↓ | ↓↓ | [45, 105] |
IGF-1 | ↑ | ↓ | ↓ | [54] |
IL-1α | ↑↑ | ↓ | ND | [54] |
IL-1𝛽 | ↑↑ | ↓ | ↑ | [54, 105, 106] |
IL-6 | ↑ | ↓ | ↓ | [105] |
↔ | ↔ | ↔ | [45] | |
IL-8 | ↑ | ↓ | ↓ | [105] |
IL-1RA | ↑ | ↓ | ↓ | [105] |
MCP-1 (CCL2) | ↑ | ↓ | ↓ | [45, 105] |
↔ | ↔ | ↔ | [45] | |
MIP-1α (CCL3) | ↓ | ↑ | + | [107, 108] |
MIP-1𝛽 (CCL4) | + | - | - | [105] |
OPN | ↓ | ↑ | ↓ | [109] |
PDGF-AA | ↑ | ↓ | ↓ | [105, 107] |
PDGF-AB | ↑ | ↓ | - | [107, 110] |
PDGF-BB | - | ↓ | - | [105] |
PGE2 | ↓ | ↓ | ↓ | [106] |
PlGF | ↓ | ↓↓ | ↑ | [105] |
SDF-1 | ↑ | ↑ | ↓ | [111, 112] |
SDF-1α | ↔ | ↔ | ↔ | [45] |
TGF-𝛽1 | ↔ | ↔ | ↔ | [105] |
TGF-𝛽2 | ↑ | ↓ | ↓ | [105] |
VEGF-A | ↑ | ↓ | ↓ | [45] |
VEGF-D | ↑ | ↓ | ↓ | [105, 107] |
MMPs and TIMPS | ||||
MMP-1 | ↑ | ↓ | ↑↑ | [105] |
MMP-2 | ↔ | ↑ | ↔ | [113] |
MMP-3 | ↓ | ↓ | ↑ | [105] |
MMP-7 | ↓ | ↑ | - | [105] |
MMP-8 | - | ↑ | - | [105] |
MMP-13 | - | - | + | [105] |
TIMP-1 | ↔ | ↔ | ↔ | [113] |
TIMP-2 | ↔ | ↔ | ↔ | [113] |
Adhesion molecules and receptors | ||||
CCR2 | ↑ | ↓ | ↓ | [54] |
CXCR4 | ↑ | ↓ | ↓ | [114] |
Flt-1 (VEGFR1) | ↑ | ↓ | ND | [54] |
ICAM-1 | ↑↑ | ↓ | ↑ | [45] |
Integrin α4 | ↑↑ | ↓ | - | [54] |
PDGF-Ra | ↔ | ↔ | [107] | |
PDGF-Rb | ↑ | ↓ | ↓ | [107] |
VCAM-1 | ↓ | ↑ | ↓ | [45] |
Immunoregulatory molecules | ||||
B7-H3 (CD276) | + | + | + | [71] |
CD200 | ↑ | ↓ | ↓↓ | [54, 115] |
Galectin 1 | ↑ | ↑ | ↓ | [113] |
HLA-ABC | ↔ | ↔ | ↔ | [54, 116] |
HLA-DR | ↔ | ↔ | ↔ | [54, 116] |
HLA-G | ↑ | ↓ | ↓ | [54, 116] |
HLA-E | ↑ | ↓ | ↓ | [54, 117] |
HLA-F | ↑ | ↓ | - | [54, 117] |
IDO | ↔ | ↔ | ↔ | [45] |
↑↑ | ↑ | ND | [118] | |
IP-10 | ↑ | ↓ | ↓ | [105] |
LIF | ↑ | ↓ | ↓ | [54, 113] |
PD-L1 (B7-H1) | ↑ | ↓ | + | [54, 119] |
PD-L2 (B7-DC/CD273) | ↑ | ↓ | + | [54, 119] |
RANTES (CCL5) | ↑ | ↓ | ↓ | [105] |
TLR-1 | ↔ | ↔ | ↔ | [106] |
TLR-2 | ↔ | ↔ | ↔ | [106] |
TLR-3 | ↔ | ↔ | ↔ | [106] |
TLR-4 | - | ↔ | ↔ | [106] |
TLR-5 | ↔ | ↔ | ↔ | [106] |
TLR-6 | ↔ | ↔ | ↔ | [106] |
TLR-9 | ↔ | ↔ | ↔ | [106] |
Expression: ↑: higher; ↑↑: significantly higher; ↓: lower; ↓↓: significantly lower; ↔: similar; +: qualitatively expressed, but not quantified; -: not expressed; ND: not detected.