Table 2.

Gene sets enriched in high-expression BACH1 cases.

Gene set name/signal pathway	NES	P value	Q value
HALLMARK_OXIDATIVE_PHOSPHORYLATION	-2.575	0.002	0.002
HALLMARK_MYC_TARGETS_V1	-1.448	0.002	0.002
HALLMARK_DNA_REPAIR	-1.981	0.002	0.002
HALLMARK_MYC_TARGETS_V2	-1.964	0.002	0.002
HALLMARK_ANGIOGENESIS	2.114	0.002	0.002
HALLMARK_ANDROGEN_RESPONSE	1.783	0.002	0.002
HALLMARK_PROTEIN_SECRETION	1.657	0.002	0.002
HALLMARK_IL6_JAK_STAT3_SIGNALING	1.908	0.002	0.002
HALLMARK_TGF_BETA_SIGNALING	1.860	0.002	0.002
HALLMARK_HYPOXIA	1.559	0.003	0.002
HALLMARK_G2M_CHECKPOINT	2.300	0.003	0.002
HALLMARK_COMPLEMENT	1.915	0.003	0.002
HALLMARK_APOPTOSIS	1.411	0.003	0.002
HALLMARK_E2F_TARGETS	1.589	0.003	0.002
HALLMARK_INTERFERON_GAMMA_RESPONSE	1.884	0.003	0.002
HALLMARK_MITOTIC_SPINDLE	2.151	0.003	0.002
HALLMARK_TNFA_SIGNALING_VIA_NFKB	2.265	0.003	0.002
HALLMARK_APICAL_JUNCTION	1.645	0.003	0.002
HALLMARK_IL2_STAT5_SIGNALING	1.877	0.003	0.002
HALLMARK_KRAS_SIGNALING_UP	2.349	0.003	0.002
HALLMARK_MTORC1_SIGNALING	1.372	0.003	0.002
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	3.165	0.003	0.002
HALLMARK_INFLAMMATORY_RESPONSE	2.423	0.003	0.002
HALLMARK_PEROXISOME	-1.526	0.010	0.006
HALLMARK_XENOBIOTIC_METABOLISM	-1.393	0.015	0.009
HALLMARK_COAGULATION	1.291	0.024	0.013
HALLMARK_HEDGEHOG_SIGNALING	1.536	0.026	0.014
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	-1.481	0.032	0.016

NES: normalized enrichment score; NOM: nominal. Gene sets with P value < 0.05 and Q value < 0.05 are considered as significant.