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Schematic of keratinocyte activation by hypoxia treatment: the primary event in this process is the production of ROS in response to hypoxia treatment. ROS function as secondary messengers and stimulate SOX2 expression and subsequent activation of Wnt/β-catenin in HaCaT cells. The activation of Wnt/β-catenin, in turn, induces EMT, accelerates migration, and promotes wound healing.
