Figure 3.

Experimental data for capillary insulin efflux into the interstitial space best fits the model for fluid phase transport across the capillary endothelium (A). Insulin movement across the capillary endothelium is unsaturable. Ins-647 and insulin have equal bioactivity and the total insulin dose is the sum of both. Kinetics for the gradient decay constant across for insulin movement from capillary to interstitial space is constant over a range (0.5 to 16 U/kg body weight) of insulin doses (B). Kinetics for the insulin movement from the capillary to interstitial space is unaffected by the insulin receptor blocker, S961 (C).