Table 2.
Univariate and Multivariate Logistic Regression Analyses to Predict Clinical Response at 52 Weeks.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | p value | OR | 95%CI | p value | |
| Age | 1.003 | (0.965-1.041) | 0.89 | |||
| Sex (male/female) | 1.429 | (0.375-5.437) | 0.60 | |||
| Weight | 1.036 | (0.975-1.100) | 0.28 | |||
| Duration of UC | 1.004 | (0.994-1.015) | 0.44 | |||
| Extent of disease (extensive/left-side) | 0.917 | (0.227-3.704) | 0.90 | |||
| Concomitant treatment | ||||||
| 5-aminosalicylic acid (yes/no) | 1.077 | (0.222-5.219) | 0.93 | |||
| Corticosteroid (yes/no) | 0.333 | (0.082-1.348) | 0.12 | |||
| Immunomodulators (yes/no) | 11.786 | (2.041-68.061) | 0.006 | 27.229 | (1.897-390.76) | 0.015 |
| Cytapheresis (yes/no) | 6.154 | (0.637-59.466) | 0.12 | |||
| Previous treatment | ||||||
| Infliximab (yes/no) | 1.500 | (0.218-10.304) | 0.68 | |||
| Tacrolimus (yes/no) | 4.571 | (0.456-45.857) | 0.20 | |||
| CRP at starting ADA, mg/dL | 1.245 | (0.871-1.780) | 0.23 | |||
| CRP after 8 weeks, mg/dL | 0.900 | (0.522-1.550) | 0.70 | |||
| Partial Mayo score at starting ADA | 0.905 | (0.600-1.366) | 0.64 | |||
| Partial Mayo score at 8 weeks | 0.528 | (0.332-0.840) | 0.007 | 0.406 | (0.204-0.809) | 0.010 |
UC: ulcerative colitis, ADA: adalimumab, OR: odds ratio, CI: confidence interval