Table 2.
Logistic regression results of the PRS and APOE for Alzheimer’s disease, vascular dementia, mixed dementia, and all-cause dementia.
| Alzheimer’s disease, n = 103 | Vascular dementia, n = 111 | Mixed dementia, n = 58 | All-cause dementia, n = 359 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | OR (95% CI) | p value | n | OR (95% CI) | p value | n | OR (95% CI) | p value | n | OR (95% CI) | p value | |
| PRS per SD | 103 | 1.70 (1.45–1.99) | <0.0001 | 111 | 1.21 (1.01–1.46) | 0.04 | 58 | 1.16 (0.89–1.52) | 0.27 | 359 | 1.36 (1.23–1.51) | <0.0001 |
| PRS per SDa | 103 | 1.52 (1.26–1.84) | <0.0001 | 111 | 1.22 (0.98–1.50) | 0.07 | 58 | 1.02 (0.74–1.40) | 0.90 | 359 | 1.30 (1.15–1.47) | <0.0001 |
| PRS− | 50 | Reference | 72 | Reference | 40 | Reference | 224 | Reference | ||||
| PRS+ | 53 | 3.40 (2.28–5.09) | <0.0001 | 39 | 1.65 (1.10–2.47) | 0.02 | 18 | 1.40 (0.79–2.50) | 0.25 | 135 | 1.91 (1.51–2.42) | <0.0001 |
| PRS Q1 | 19 | Reference | 29 | Reference | 18 | Reference | 81 | Reference | ||||
| PRS Q2 | 15 | 0.74 (0.37–1.49) | 0.40 | 16 | 0.49 (0.26-0.92) | 0.03 | 14 | 0.75 (0.36–1.54) | 0.43 | 69 | 0.79 (0.56–1.11) | 0.17 |
| PRS Q3 | 16 | 0.84 (0.43–1.66) | 0.62 | 27 | 0.91 (0.53–1.57) | 0.73 | 10 | 0.53 (0.24–1.17) | 0.12 | 77 | 0.93 (0.66–1.29) | 0.65 |
| PRS Q4 | 53 | 3.17 (1.84–5.46) | <0.001 | 39 | 1.40 (0.85–2.31) | 0.19 | 16 | 0.98 (0.48–1.98) | 0.95 | 132 | 1.80 (1.33–2.44) | <0.001 |
| APOE4− | 51 | Reference | 70 | Reference | 38 | Reference | 216 | Reference | ||||
| APOE4+ | 52 | 3.34 (2.24–4.99) | <0.0001 | 41 | 1.84 (1.23–2.74) | <0.01 | 20 | 1.75 (1.00–3.07) | <0.05 | 143 | 2.20 (1.74–2.78) | <0.0001 |
| APOE ε3ε3 | 39 | Reference | 52 | Reference | 29 | Reference | 166 | Reference | ||||
| APOE ε3ε4 | 42 | 3.42 (2.17–5.37) | <0.0001 | 33 | 1.94 (1.23–3.05) | <0.01 | 13 | 1.46 (0.75–2.87) | 0.27 | 109 | 2.09 (1.60–2.73) | <0.0001 |
| APOE ε4ε4 | 8 | 13.89 (5.88–32.82) | <0.0001 | 2 | 1.88 (0.42–8.36) | 0.41 | 6 | 14.81 (5.12–42.87) | <0.0001 | 18 | 6.86 (3.71–12.69) | <0.0001 |
| PRS− APOE4− | 43 | Reference | 63 | Reference | 34 | Reference | 193 | Reference | ||||
| PRS+APOE4− | 8 | 1.55 (0.71–3.37) | 0.27 | 7 | 0.90 (0.40–2.00) | 0.80 | 4 | 0.88 (0.30–2.55) | 0.35 | 23 | 0.95 (0.60–1.52) | 0.84 |
| PRS− APOE4+ | 7 | 1.42 (0.63–3.23) | 0.40 | 9 | 1.24 (0.60–2.56) | 0.56 | 6 | 1.54 (0.63–3.79) | 0.81 | 31 | 1.44 (0.95–2.19) | 0.09 |
| PRS+APOE4+ | 45 | 4.59 (2.96–7.11) | <0.0001 | 32 | 2.08 (1.34–3.25) | <0.01 | 14 | 1.82 (0.95–3.48) | 0.07 | 112 | 2.54 (1.95–3.30) | <0.0001 |
Model covariates included age, sex, education, and 10 principal components. Bolded results indicate achievement of statistical significance, p < 0.05.
APOE4+ ≥1 APOE ε4 allele, PRS polygenic risk score, Q quartile, SD standard deviation.
aAdditionally adjusted for APOE status.