Table 3.
Dementia diagnoses prediction by PRS & APOE4 status stratified by sex, age at baseline, and education.
| n | PRS + vs. PRS− | APOE4 + vs. APOE4− | PRS+ & APOE4+ vs. PRS− & APOE4− | Interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PRS | APOE4 | PRS&APOE4 | ||||||||
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | p value | p value | p value | ||
| Alzheimer’s disease | ||||||||||
| Female | 60 | 3.50 (2.05–5.99) | <0.0001 | 3.33 (1.94–5.70) | <0.0001 | 4.60 (2.59–8.16) | <0.0001 | 0.91 | 0.85 | 0.99 |
| Male | 43 | 3.58 (1.91–6.71) | <0.0001 | 3.73 (2.00–6.94) | <0.0001 | 5.08 (2.51–10.26) | <0.0001 | |||
| 50–64 years | 30 | 3.44 (1.66–7.14) | <0.001 | 3.77 (1.81–7.84) | 0.001 | 4.75 (2.13–10.60) | 0.0001 | 0.92 | 0.75 | 0.99 |
| 65–75 years | 73 | 3.48 (2.15–5.63) | <0.0001 | 3.13 (1.94–5.06) | <0.0001 | 4.45 (2.64–7.49) | <0.0001 | |||
| ≤9 years educ. | 85 | 3.36 (2.15–5.25) | <0.0001 | 3.59 (2.30–5.61) | <0.0001 | 4.76 (2.93–7.73) | <0.0001 | 0.52 | 0.57 | 0.81 |
| >9 years educ. | 17 | 4.67 (1.64–13.31) | <0.01 | 2.58 (0.92–7.24) | 0.07 | 4.80 (1.54–14.96) | <0.01 | |||
| Vascular dementia | ||||||||||
| Female | 59 | 1.73 (0.98–3.05) | 0.06 | 2.09 (1.20–3.63) | <0.01 | 2.19 (1.15–4.18) | 0.02 | 0.74 | 0.43 | 0.58 |
| Male | 52 | 1.60 (0.88–2.91) | 0.12 | 1.61 (0.89–2.91) | 0.11 | 2.00 (1.06–3.75) | 0.03 | |||
| 50–64 years | 27 | 2.17 (0.99–4.75) | 0.05 | 1.77 (0.80–3.91) | 0.16 | 2.26 (0.93–5.46) | 0.07 | 0.59 | 0.85 | 0.76 |
| 65–75 years | 84 | 1.59 (0.99–2.55) | 0.05 | 1.93 (1.21–3.05) | <0.01 | 2.14 (1.28–3.57) | <0.01 | |||
| ≤9 years educ. | 83 | 1.41 (0.87–2.29) | 0.17 | 1.43 (0.88–2.31) | 0.15 | 1.57 (0.91–2.70) | 0.11 | 0.24 | 0.06 | 0.12 |
| >9 years educ. | 23 | 2.68 (1.14–6.31) | 0.02 | 3.64 (1.54–8.57) | <0.01 | 4.21 (1.67–10.62) | <0.01 | |||
| Mixed dementia | ||||||||||
| Female | 34 | 1.01 (0.38–2.69) | 0.99 | 1.73 (0.70–4.28) | 0.24 | 1.23 (0.38–4.05) | 0.73 | 0.37 | 0.77 | 0.44 |
| Male | 24 | 1.78 (0.85–3.74) | 0.13 | 1.87 (0.90–3.89) | 0.10 | 2.32 (1.04–5.17) | 0.04 | |||
| 50–64 years | 10 | 4.54 (1.25–16.51) | 0.02 | 4.23 (1.17–15.33) | 0.03 | 6.08 (1.41–26.19) | 0.02 | 0.02 | 0.07 | 0.02 |
| 65–75 years | 48 | 1.10 (0.56–2.15) | 0.79 | 1.43 (0.75–2.73) | 0.27 | 1.34 (0.62–2.90) | 0.45 | |||
| ≤9 years educ. | 44 | 1.23 (0.61–2.46) | 0.56 | 1.34 (0.68–2.63) | 0.40 | 1.43 (0.65–3.14) | 0.38 | 0.40 | 0.04 | 0.17 |
| >9 years educ. | 11 | 2.05 (0.58–7.21) | 0.26 | 4.57 (1.24–16.88) | 0.02 | 4.13 (1.02–16.80) | <0.05 | |||
| All-cause dementia | ||||||||||
| Female | 182 | 1.87 (1.33–2.63) | <0.001 | 2.16 (1.54–3.04) | <0.0001 | 2.45 (1.67–3.60) | <0.0001 | 0.78 | 0.68 | 0.75 |
| Male | 177 | 2.05 (1.47–2.86) | <0.0001 | 2.32 (1.67–3.22) | <0.0001 | 2.74 (1.91–3.94) | <0.0001 | |||
| 50–64 years | 95 | 2.36 (1.56–3.59) | <0.0001 | 2.63 (1.74–3.98) | <0.0001 | 3.03 (1.92–4.79) | <0.0001 | 0.40 | 0.32 | 0.35 |
| 65–75 years | 264 | 1.78 (1.35–2.36) | <0.0001 | 1.97 (1.49–2.60) | <0.0001 | 2.30 (1.69–3.14) | <0.0001 | |||
| ≤9 years educ. | 279 | 1.83 (1.39–2.41) | <0.0001 | 1.98 (1.51–2.59) | <0.0001 | 2.32 (1.72–3.14) | <0.0001 | 0.42 | 0.10 | 0.25 |
| >9 years educ. | 66 | 2.22 (1.30–3.77) | <0.01 | 2.97 (1.74–5.06) | <0.0001 | 3.31 (1.84–5.93) | <0.0001 | |||
All analyses stratified by 10 principal components and: sex were adjusted for age and education, age for sex and education, and education for sex and age. Bolded results indicate achievement of statistical significance, p < 0.05.
APOE4 apolipoprotein E ε4, PRS polygenic risk score, Educ. education.