Table 1.
Clinical demographic data for subjects used in this study.
| Sex (M/F) | Age (years) | Braak stage | ApoE (E/E) | Onset | Postmortem delay (hr:minutes) | |
|---|---|---|---|---|---|---|
| For binding studies | ||||||
| Control | F | 50 | 1 | 3/3 | N/A | 4:10 |
| M | 62 | 1 | 3/3 | N/A | 7:20 | |
| F | 71 | 1 | 3/2 | N/A | 7:10 | |
| F | 77 | 1 | 3/3 | N/A | 2:55 | |
| M | 78 | 1 | 3/3 | N/A | <17:40 | |
| M | 79 | 2 | 3/3 | N/A | 9:00 | |
| F | 84 | 1 | 3/3 | N/A | 6:55 | |
| 3M/4F | 71.5 ± 11.8 | 1–2 | 7 E3 0 E4 | 7.7 ± 4.7 | ||
| Alzheimer’s disease | F | 59 | 5 | 4/4 | EOAD | 4:20 |
| F | 66 | 5 | 4/3 | EOAD | 6:30 | |
| M | 70 | 4 | 4/4 | EOAD | 4:00 | |
| M | 78 | 5 | 4/4 | LOAD | 6:35 | |
| F | 81 | 5 | 4/3 | LOAD | 6:15 | |
| F | 85 | 4 | 3/3 | LOAD | 6:00 | |
| 2M/4F | 73.1 ± 9.8 | 4–5 | 1 E3 5 E4 | 3EOAD/3LOAD | 5.5 ± 1.0 | |
| For large frozen section autoradiography studies | ||||||
| Control | F | 56 | N/A | N/A | N/A | N/A |
| Sporadic Alzheimer’s diseasea | F | 79 | V | 4/4 | LOAD | 16:00 |
| AβPPArca | M | 64 | VI | 3/3 | EOAD | 12:00 |
Bold values show the total number of male and female cases used in the study from control and AD cases as well as the means ± standard deviation of age, Braak stage, ApoE allele forms, and postmortem delay time from these cases.
AβPPArc Arctic amyloid-β protein precursor mutation, ApoE Apolipoprotein E, M Male, F Female, EOAD Early onset alzheimer’s disease, LOAD Late onset alzheimer’s disease, N/A Not applicable/available.
aSporadic Alzheimer’s disease and AβPPArc cases have been also reported and described in our previous publications [39, 40, 70].