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. 2020 Jan 15;26(10):5636–5657. doi: 10.1038/s41380-019-0610-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 11 — Identification of relevant SNPs within the MIR298 gene boundary. LD blocks for region proximal to MIR298 gene reveals four blocks of SNPs. The top thick line represents a strand of a chromosome. The white bars on the blue line of the chromosome are SNPs (single nucleotide polymorphisms) that have been identified and sequenced. These SNP locations or loci are labeled in this picture standard nomenclature. Each of these SNPs has a name that has the format rs#…# where “#…#” is a numeric code of varying length. Each SNP is represented by a labeled gray triangle below the thick blue line (the chromosome). We identified 33 common SNPs (minor allele frequency (MAF) ≥ 0.05) within ±10 kb from the MIR298 gene boundary. Of the 33 SNPs, 32 exist within four LD (linkage disequilibrium) blocks of 2, <1, 9, and 1 kb in length.