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. 2020 Jan 15;26(10):5636–5657. doi: 10.1038/s41380-019-0610-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 12 — SNPs proximal to MIR298 gene with AD-associated phenotypes. a MIR298 resides on chromosome 20, in band q13.3. Two potentially functional SNPs, rs6070629, and rs7925998, are at ~8.4 kb upstream and 1.9 kb downstream of the MIR298 gene. An apparently nonfunctional SNP (rs71828623) lies within the miR-298 seed sequence. The 88-base pre-miR-298 contains the mature miR-298 sequence. Position of the nonfunctional rs71828623 is indicated. b SNP rs6070629 associated with elevation of CSF levels of a specific phosphorylated τ in a dose-dependent manner. The minor allele (“G”) associates with elevated p-τ levels. c SNP rs7925998 associated with reduction of CSF Aβ42. The presence of either one or two minor “C” alleles of rs7925998 associated with a reduction of CSF Aβ42.