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. 2021 Sep 3;26(10):6054–6064. doi: 10.1038/s41380-021-01266-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Boxplots showing distribution of gene expression level (represented as log2 FPKM) by AD status and APOE genotype for top-ranked DEGs among APOE ε2/ε3 subjects in the ROSMAP dataset. b Boxplots showing the distribution of rank-transformed plaque score and Braak stage by APOE genotype and AD status among subjects in the ROSMAP and FHS/BUADC datasets. c, d Scatterplots showing the correlation of expression of the top-ranked DEGs among APOE ε2/ε3 subjects with rank-transformed Braak stage (c) and plaque score (d) in the ROSMAP dataset according to APOE genotype depicted by color (ε2/ε3 = dark blue, ε3/ε3 = light blue, ε3/ε4 = red, total = black). Coordinates for expression (quantified as log2 FPKM) plotted against plaque or Braak score for each subject are shown as dots and their correlation across subjects is represented by fitted solid lines.