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. 2021 Sep 3;26(10):6054–6064. doi: 10.1038/s41380-021-01266-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Heatmap showing the association of gene expression with and AD-related proteins. Genes shown are differentially expressed in the total sample (P < 10⁻⁶) and among APOE ε2/ε3 subjects (P < 10⁻³), or were selected from the M01 network and are significantly differentially expressed between AD and control oligodendrocytes. Significant (P < 6.3 × 10⁻³) associations are marked by an asterisk. b Scatterplots showing association of expression of genes in APOE ε2/ε3 co-expression network (C4A, C4B, and HSPA2) with rank-transformed pTau231/tTau ratio. Coordinates for each subject are shown as color-coded dots (red = AD, blue = controls) and their correlation across subjects (within AD cases and control groups, and for the total group) is represented by fitted solid lines (black = combined sample).