Table 1.

Differentially expressed genes among APOE ε2/ε3 subjects.

Gene	APOE ε2/ε3		APOE ε3/ε3		APOE ε3/ε4		Total
	Z	P value	Z	P value	Z	P value	Z	P value
C4A	4.28	1.9 × 10−5	2.78	5.4 × 10−3	2.48	0.01	5.73	1.0 × 10−8
C4B	4.10	4.2 × 10−5	3.50	4.7 × 10−4	2.17	0.03	6.08	1.2 × 10−9
GFAP	4.12	3.8 × 10−5	4.03	5.6 × 10−5	1.51	0.13	6.89	5.4 × 10−12
NPNT	3.65	2.6 × 10−4	6.34	2.4 × 10−10	1.58	0.11	8.58	9.3 × 10−18

Gene expression levels were compared between AD and control brains separately in the ROSMAP, MAYO, and FHS/BUADC datasets, and results were combined by meta-analysis.

Selected genes surpassed significance thresholds p < 10⁻³ in the APOE 2/ε3 group and p < 10⁻⁶ in the total sample.