Table 2.
Diagnostic parameters for plasma tau and NfL in sCJD, derived from Receiver Operating Characteristic (ROC) analysis.
| sCJD… | vs Healthy controls | vs All non-prion disease | vs ‘CJD mimics’ | |||
|---|---|---|---|---|---|---|
| Plasma biomarker | tau | NfL | tau | NfL | tau | NfL |
|
Area under ROC curve |
0.913 | 1.0 | 0.808 | 0.912 | 0.809 | 0.724 |
| Cut-off (pg/mL) (Youden method) | >3.27 | >25.87 | >6.11 | >60.65 | >3.81 | >60.65 |
|
Sensitivity (95% C.I.) |
80% (73–87%) |
100% (n/a) |
57% (42–73%) |
93% (89–97%) |
74% (59–88%) |
93% (88–98%) |
|
Specificity (95% C.I.) |
97% (90–100%) |
100% (n/a) |
95% (82–100%) |
84% (75–93%) |
83% (68–99%) |
57% (39–74%) |