Table 1.
General subject characteristics.
| CN (N = 90) | SMC (N = 91) | EMCI (N = 41) | LMCI (N = 36) | AD (N = 24) | Total (N = 282) | p value | |
|---|---|---|---|---|---|---|---|
| Age, yrs | 0.222e | ||||||
| Mean (SD) | 72.9 (7.4) | 71.2 (6.3) | 72.7 (7.7) | 74.1 (8.1) | 74.2 (9.8) | 72.6 (7.5) | |
| Range | 56.5–91.5 | 57.1–90.4 | 57.8–88.1 | 55.9–88.4 | 55.5–89.2 | 55.5–91.5 | |
| Sex | 0.003f | ||||||
| Male | 35 (38.9%) | 32 (35.2%) | 23 (56.1%) | 21 (58.3%) | 17 (70.8%) | 128 (45.4%) | |
| Female | 55 (61.1%) | 59 (64.8%) | 18 (43.9%) | 15 (41.7%) | 7 (29.2%) | 154 (54.6%) | |
| Education, yrs | 0.065e | ||||||
| Mean (SD) | 17.2 (2.2) | 16.7 (2.1) | 16.2 (2.9) | 16.0 (2.4)a | 16.6 (2.7) | 16.7 (2.4) | |
| Range | 11.0–20.0 | 12.0–20.0 | 12.0–20.0 | 10.0–20.0 | 12.0–20.0 | 10.0–20.0 | |
| APOE4 carrier | 0.034f | ||||||
| Missing (n) | 0 | 1 | 0 | 0 | 0 | 1 | |
| No | 63 (70.0%) | 52 (57.8%) | 27 (65.9%) | 19 (52.8%) | 9 (37.5%) | 170 (60.5%) | |
| Yes | 27 (30.0%) | 38 (42.2%) | 14 (34.1%) | 17 (47.2%) | 15 (62.5%) | 111 (39.5%) | |
| MMSE | <0.001e | ||||||
| Mean (SD) | 29.0 (1.2) | 29.3 (1.0) | 28.3 (1.4)b | 27.2 (2.3)a.,b.,c | 23.2 (2.7)a.,b.,c.,d. | 28.3 (2.3) | |
| Range | 25.0–30.0 | 26.0–30.0 | 25.0–30.0 | 19.0–30.0 | 17.0–29.0 | 17.0–30.0 | |
| CDR | <0.001e | ||||||
| Mean (SD) | 0.0 (0.1) | 0.0 (0.0) | 0.5 (0.1)a.,b. | 0.5 (0.1)a.,b. | 0.8 (0.3)a.,b.,c.,d. | 0.2 (0.3) | |
| Range | 0.0–0.5 | 0.0–0.0 | 0.0–0.5 | 0.0–0.5 | 0.5–1.0 | 0.0–1.0 | |
| ADNI memory composite score | <0.001e | ||||||
| Mean (SD) | 1.1 (0.5) | 1.0 (0.6) | 0.5 (0.4)a.,b. | 0.1 (0.5)a.,b.,c | −0.7 (0.6)a.,b.,c.,d. | 0.7 (0.7) | |
| Range | −0.2 −2.7 | −0.2 −2.3 | −0.3 −1.4 | −1.0 −1.2 | −1.6 −0.5 | −1.6 −2.7 | |
| Follow up time interval, months | <0.001e | ||||||
| Missing (n) | 30 | 25 | 5 | 1 | 6 | 69 | |
| Mean (SD) | 23.6 (6.6) | 24.6 (5.2) | 19.4 (8.5) | 17.8 (7.0)b | 20.2 (7.2) | 22.0 (7.1) | |
| Range | 0.0–33.7 | 11.9–32.0 | 0.0–35.2 | 4.1–31.0 | 10.4–30.4 | 0.0–35.2 | |
a,b,c,dDenote a significant difference from CN, SMC, EMCI and LMCI, respectively, with Tukey Post Hoc. (p < 0.05).
a.,b.,c.,d.Denote a significant difference from CN, SMC, EMCI and LMCI, respectively, with Tukey Post Hoc. (p < 0.001).
AD Alzheimer’s disease, CDR clinical dementia rating, CN cognitively normal, EMCI early MCI, LMCI late MCI, MCI mild cognitive impairment, MMSE mini-mental state examination, SMC subjective memory concern.
eLinear Model ANOVA.
fPearson’s Chi-squared test.