Table 1.

Putative pathogenic rare risk variants in PIAS2, JAK2, TYK2, and AKT1 associated with Parkinson disease.

PIAS2/chr18	Allele1	Allele2	SE	Meta_P
chr18:42747317	t	c	0.1619	0.04771
chr18:42719495	a	g	0.1628	0.04853

JAK2/chr9	Allele1	Allele2	SE	Meta P
chr9:4977057	t	c	0.1056	0.02126
rs7863708	t	c	0.0637	0.02209
rs7026646	a	g	0.0618	0.02856
rs7857730	t	g	0.0256	0.03138
rs2031906	t	c	0.0256	0.03521
rs10117591	a	g	0.0254	0.03582
rs7847294	a	c	0.0254	0.03743
rs10115312	t	g	0.0262	0.03766
rs7861599	t	c	0.0257	0.03947
rs4372063	a	g	0.0262	0.04055
rs2149556	t	c	0.0256	0.04097
rs7034878	a	c	0.0256	0.04097
rs9987451	t	c	0.0254	0.04242
rs10815158	a	g	0.0254	0.04322
rs3780378	t	c	0.0254	0.04322
rs10815146	a	t	0.0254	0.0441
rs10815144	a	g	0.0254	0.04417
rs7852988	a	c	0.0254	0.04417
rs7034753	a	g	0.0254	0.04491
rs4587378	t	c	0.0261	0.04607
rs1328918	a	g	0.0256	0.04644
rs4282620	a	c	0.0256	0.04671
rs7019858	t	c	0.0256	0.04671
rs7033052	c	g	0.0258	0.04939

TYK2/chr19	Allele1	Allele2	SE	Meta P
chr19:10349680	a	g	0.0713	0.007884
chr19:10349007	a	g	0.1136	0.04181

AKT1/chr14	Allele1	Allele2	SE	Meta P
rs3803304	c	g	0.0344	0.001726
chr14:104314779	a	g	0.0443	0.004011
chr14:104314770	a	g	0.0526	0.008963
rs10149779	a	g	0.0475	0.01566
rs3730358	a	g	0.0621	0.02332
chr14:104328847	a	g	0.0631	0.04163
rs2498800	t	c	0.0284	0.04245
rs2494734	c	g	0.029	0.04262
rs12590657	c	g	0.0293	0.04303
rs2498797	t	c	0.029	0.04405
rs3001371	t	c	0.0292	0.04445
rs2494733	c	g	0.0288	0.04454
rs2494731	c	g	0.0281	0.04508
chr14:104328399	a	g	0.063	0.04511
rs1130233	t	c	0.0298	0.04594