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. 2021 Aug 12;26(10):5557–5567. doi: 10.1038/s41380-021-01257-0

Fig. 5. Impaired PC spike-gamma coupling in AppNL-G-F mice appears at 6 m.o. (KA present).

Fig. 5

a Representative traces from concomitant recordings of PC firing and LFP gamma oscillations at 2 m.o., 4 m.o. and 6 m.o. from WT (gray) and AppNL-G-F (red). b Representative polar plots of a representative PC AP-phase angle at 2 m.o., 4 m.o. and 6 m.o. from WT (gray) and AppNL-G-F (red). c Summary of PC vector length data at 2 m.o. (WT n:10 (N = 8) vs AppNL-G-F n:12 (N = 8), p = 0.9313), 4 m.o. (WT n:9 (N = 6) vs AppNL-G-F n:9 (N = 8), p = 0.9522) and 6 m.o. (WT n:10 (N = 6) vs AppNL-G-F n:10 (N = 8), p = 0.0491) for WT (gray bars) and AppNL-G-F (red bars). d Summary of PC phase angle data at 2 m.o. (p = 0.8264), 4 m.o. (p = 0.5664) and 6 m.o. (p = 0.5456) for WT (gray bars) and AppNL-G-F (red bars). e Summary of PC firing rate data at 2 m.o. (p = 0.9646), 4 m.o. (p = 0.0943) and 6 m.o. (p = 0.9646) for WT (gray bars) and AppNL-G-F (red bars). Data in bar graphs are presented as mean ± SEM. “n” indicates the number of cells. “N” indicates the number of mice. Statistics from two-way ANOVA followed by a Holm–Sidak’s multiple comparisons test (Supplementary Table 1). *p < 0.05.