Table 2.

Excess of the Alzheimer’s disease (AD) risk for the ε4 carriers who carry and do not carry minor alleles of rs2075650 and rs12721046.

MA coding	Sample	N_total	N_AD	Beta	SE	Odds ratio	p-value
100	Reference
111	Pooled	3000	718	0.28	0.12	1.32	2.51E-02
111	ADGC	1437	1230	0.71	0.14	2.03	8.29E-07
111	Meta	4437	1948	0.46	0.09	1.59	8.46E-07
1XY	Pooled	3558	863	0.32	0.12	1.38	7.73E-03
1XY	ADGC	1733	1463	0.61	0.14	1.85	8.39E-06
1XY	Meta	5291	2326	0.45	0.09	1.57	7.81E-07
200	Reference
222	Pooled	265	155	1.40	0.63	4.05	2.73E-02
222	ADGC	310	299	1.56	0.67	4.76	1.96E-02
222	Meta	575	454	1.48	0.46	4.37	1.34E-03
2XY	Pooled	468	257	1.23	0.56	3.42	2.77E-02
2XY	ADGC	559	535	1.25	0.63	3.49	4.75E-02
2XY	Meta	1027	792	1.24	0.42	3.45	3.05E-03
100+200	Reference
111+222	Pooled	3265	873	0.41	0.12	1.51	6.95E-04
111+222	ADGC	1747	1529	0.86	0.14	2.37	4.56E-10
111+222	Meta	5012	2402	0.61	0.09	1.84	2.68E-11
1XY+2XY	Pooled	4026	1120	0.48	0.12	1.61	5.69E-05
1XY+2XY	ADGC	2292	1998	0.84	0.13	2.32	2.08E-10
1XY+2XY	Meta	6318	3118	0.64	0.09	1.89	4.69E-13

Column MA coding shows compound genotypes coded by the number of minor alleles (0, 1, or 2) in each SNP ordered as rs429358, rs2075650 and rs12721046. Symbols “X” and “Y” denote aggregated compound genotypes; these symbols take values of 0, 1, or 2 but not simultaneously 0.

Column Sample shows the results for the pooled sample and the AD Genetics Consortium (ADGC) sample, and the results from the meta-analysis of the pooled and ADGC samples. The pooled sample includes the NIA Late Onset Alzheimer’s disease Family Study, the Health and Retirement Study, the Cardiovascular Health Study, and the Framingham Heart Study original and offspring cohorts. N_total is the total number of subjects; N_AD is the number of AD cases; SE is the standard error.