Skip to main content
. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Shock. 2022 Feb 1;57(2):246–255. doi: 10.1097/SHK.0000000000001894

Fig. 8. Proposed mechanism for the protective role of M3.

Fig. 8.

In our proposed schema, eCIRP levels increase in hepatic I/R. eCIRP binds to TREM-1, and through signaling of pDAP12 and pSyk, inflammatory cytokines are released and contribute to liver injury. M3 acts as an inhibitor of TREM-1 via blocking the interaction of eCIRP and TREM-1, and as a result, decreases the amount of liver damage seen in hepatic I/R (Created with BioRender.com).