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. 2022 Jan 14;293:120284. doi: 10.1016/j.lfs.2021.120284

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Fig. 6 — (A) Representative traces (top) of Ca_V2.2 calcium currents (I_CaV2.2) and time courses (middle) of HEK293T cells co-transfected with Ca_V2.2 and B2R (+B2R, n = 7), or Ca_V2.2, B2R and ACE2 (+B2R + ACE2, n = 8), or Ca_V2.2, B2R and AT1R (+B2R + AT1R, n = 6), or Ca_V2.2, B2R, AT1R and ACE2 (+B2R + AT1R + ACE2, n = 7) in control condition (vehicle) and 0.5 μM BK application (+BK); 0.1 ACE2-GFP or GPCR: Ca_V2.2 molar ratio. Black and gray dots correspond to vehicle and BK traces respectively. Bars (bottom) represent the average I_CaV2.2 inhibition by BK application for each condition. One Way ANOVA and Tukey's post-test (P value estimated versus +B2R). (B) Representative traces (top) of Ca_V2.2 calcium current (I_CaV2.2) and time courses (middle) of HEK293T cells co-transfected with Ca_V2.2, and AT1R (+AT1R, n = 7), or Ca_V2.2, AT1R and B2R (+AT1R + B2R, n = 5), or Ca_V2.2, AT1R and ACE2 (+AT1R + ACE2, n = 4), or Ca_V2.2, AT1R, B2R and ACE2 (+B2R + AT1R + ACE2, n = 4) in control condition (vehicle) and 1 μM Ang II application (+Ang II); 0.1 ACE2-GFP or GPCR: Ca_V2.2 molar ratio. Black and gray dots correspond to vehicle and Ang II traces respectively. Bars (bottom) represent the average I_CaV2.2 inhibition by angiotensin II application for each condition. One Way ANOVA and Tukey's post-test (P value estimated versus +AT1R).