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. 2021 Dec 31;9:791187. doi: 10.3389/fcell.2021.791187

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Copyright © 2021 Chen, Zuo, Zhang, Xia, Lei, Zhang, Bao and You.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of MIF is more prominent in NPC patients with metastasis. (A) Representative IHC images of MIF staining in tissues collected without lymph node metastasis, with lymph node metastasis, without distant metastasis, and with distant metastasis specimens from NPC patients. (B–D) Statistical analyses of the association of MIF expression with lymph node metastasis, distant metastasis and prognosis and Kaplan-Meier analysis. All graphs show the mean ± SEM of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.