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. 2021 Dec 31;12:798652. doi: 10.3389/fendo.2021.798652

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Copyright © 2021 Chakraborty, Hegde, Praharaj, Prabhu, Patole, Shetty, Mayya, Acharya, Hande, Prabhu and Upadhya

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative quantitation of different lipids in the serum of type 2 diabetes mellitus patients with mild cognitive impairment (MCI) versus normal cognition (NC) using untargeted lipidomic analysis were presented in a heat map (A). This analysis identified a total of 646 lipids in different classes. Comparison of fold change in the log 2 transformed values of T2DM NC patients with MCI patients identified significant changes in 14 species of triacylglycerols, 11 species of sphingolipids, 5 species of phosphatidylcholine, one species each of phosphatidylethanolamine, phosphatidylinositol, and cholesterol ester. These results were visualized in a heat map (B).