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. 2021 Dec 31;12:798652. doi: 10.3389/fendo.2021.798652

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Copyright © 2021 Chakraborty, Hegde, Praharaj, Prabhu, Patole, Shetty, Mayya, Acharya, Hande, Prabhu and Upadhya

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The amount of different sphingolipids in the serum type 2 diabetes mellitus patients with mild cognitive impairment (MCI) versus normal cognition (NC) were evaluated using targeted sphingolipidomic analysis and were presented in Figure 2 . Evaluation of the total amount of different sphingolipids in MCI and NC groups revealed no significant differences between ceramides (p = 0.47), CerG2GNAc1 (p=0.46), ceramide phosphates (CerP, p=0.67), phosphorylethanolamine ceramides (CerPE, p=0.69), monohexosylceramides (Hex1Cer, p=0.09), dihexosylceramides (Hex2Cer, p=0.62), trihexosyl ceramides (Hex3Cer, p=0.35), sphingomyelins (SM, p=0.92), sphingosine (SP, p=0.8), sphingosine-1-phosphate (SPH, p=0.9) as well as phytosphingomelins (phSM, p=0.37).