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. 2021 Dec 31;12:783341. doi: 10.3389/fphys.2021.783341

FIGURE 3.

FIGURE 3

Exercise enhanced the ability of ApoA5 to inhibit TLR4 signaling pathway by lowering LPS concentrations. The hepatic protein (A,B) and relative mRNA (C) expression levels of ApoA5, TLR4, MyD88, and NF-κBp65 in LFD mice transfected with pEGF-N1-ApoA5. The LPS levels of serum in HFD + EXE mice after injection of different concentrations of LPS (D). The hepatic protein (E,F) and relative mRNA (G) expression levels of ApoA5, TLR4, MyD88, and NF-κBp65 in HFD + EXE mice after injection of different concentrations of LPS. The body weight (H), liver weight (I), and circulating LPS concentrations (J) in LFD mice transfected with pEGF-N1-ApoA5. Results are presented as the mean ± SEM, n = 4 per group. * P < 0.05 for different from the pEGF-N1 vector group or 5 μg/kg⋅wt group; ns P > 0.05 (no difference) for different from the normal saline group.