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. 2022 Jan 14;2022(1):CD000029. doi: 10.1002/14651858.CD000029.pub4

Comparison 1. Antiplatelet drug versus control in acute presumed ischaemic stroke.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Death or dependence at end of follow‐up 7 42034 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.95 [0.91, 0.99]
1.1.1 Aspirin versus control 5 41604 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.95 [0.91, 0.99]
1.1.2 PF‐03049423 versus control 1 133 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.15 [0.58, 2.28]
1.1.3 Clopidogrel loading dose versus control 1 297 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.80 [0.45, 1.42]
1.2 Deaths from any cause during treatment period 8 41483 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.92 [0.85, 1.00]
1.2.1 Aspirin versus control 4 41291 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.92 [0.85, 1.00]
1.2.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.47 [0.43, 4.99]
1.2.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.12 [0.01, 1.20]
1.3 Deaths from any cause during follow‐up 10 41929 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.93 [0.87, 0.98]
1.3.1 Aspirin versus control 5 41604 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.92 [0.87, 0.98]
1.3.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.47 [0.43, 4.99]
1.3.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.12 [0.02, 0.88]
1.3.4 PF‐03049423 versus control 1 133 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.91 [0.74, 4.93]
1.4 Deep venous thrombosis during treatment period 2 133 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.78 [0.36, 1.67]
1.4.1 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.35 [0.13, 0.95]
1.4.2 Ticlopidine versus control 1 53 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.37 [0.72, 7.73]
1.5 Pulmonary embolism during treatment period 7 41042 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.71 [0.53, 0.96]
1.5.1 Aspirin versus control 3 40850 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.71 [0.53, 0.97]
1.5.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 7.39 [0.15, 372.38]
1.5.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.13 [0.01, 2.06]
1.6 Recurrent ischaemic/unknown stroke during treatment period 9 41652 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.79 [0.70, 0.88]
1.6.1 Aspirin versus control 4 41163 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.78 [0.69, 0.88]
1.6.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
1.6.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
1.6.4 Clopidogrel loading dose versus control 1 297 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.10 [0.59, 2.06]
1.7 Symptomatic intracranial haemorrhage during treatment period 9 41652 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.18 [0.97, 1.44]
1.7.1 Aspirin versus control 4 41163 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.17 [0.96, 1.43]
1.7.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.00 [0.14, 7.38]
1.7.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.70 [0.36, 20.26]
1.7.4 Clopidogrel loading dose versus control 1 297 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.99 [0.14, 7.12]
1.8 Recurrent stroke/intracranial haemorrhage during treatment period 7 41042 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.88 [0.79, 0.97]
1.8.1 Aspirin versus control 3 40850 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.87 [0.79, 0.97]
1.8.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.00 [0.14, 7.38]
1.8.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.70 [0.36, 20.26]
1.9 Major extracranial haemorrhage during treatment period 7 41042 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.69 [1.35, 2.11]
1.9.1 Aspirin versus control 3 40850 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.69 [1.35, 2.11]
1.9.2 Aspirin plus dipyridamole versus control 1 80 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
1.9.3 Ticlopidine versus control 3 112 Peto Odds Ratio (Peto, Fixed, 95% CI) Not estimable
1.10 Complete recovery from stroke (post hoc) 2 40541 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.06 [1.01, 1.11]
1.10.1 Aspirin versus control 2 40541 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.06 [1.01, 1.11]