Pince 1981.

Study characteristics
Methods	Randomisation: sealed envelope Double blind Exclusions during trial: 9 (5 treatment, 4 control) Losses to follow‐up: none
Participants	France 80 participants 50 (62%) male Mean age: 66 years No CT before entry; 100% had lumbar puncture Presumed ischaemic stroke < 6 days since stroke onset
Interventions	Treatment: aspirin 330 mg 8 hourly (oral) + dipyridamole 75 mg 8 hourly (oral) Control: placebo Duration: 1 week
Outcomes	Death DVT (systematic I125 scan) Pulmonary embolism (symptomatic) Intracranial haemorrhage (symptomatic) Extracranial haemorrhage
Funding source	No information available
Notes	Exclusions: bleeding risk, aspirin allergy Follow‐up: 10 days
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement.
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement.
Blinding of participants and personnel (performance bias) all outcomes	Low risk	Participants and personnel blinded.
Blinding of outcome assessment (detection bias) all outcomes	Unclear risk	Not explicitly reported whether outcome assessors were aware of the intervention participants received.
Incomplete outcome data (attrition bias) all outcomes	Low risk	No concerns regarding missing outcome data.
Selective reporting (reporting bias)	Unclear risk	Prespecified analysis plan unclear.
Other bias	Unclear risk	Unpublished thesis in French, unclear of statistical plan.