Utsumi 1988.

Study characteristics
Methods	Randomisation: unknown Not blind Exclusions during trial: 1 (control) Losses to follow‐up: 0
Participants	Japan 29 participants 5 (17%) male Mean age: 63 years CT scanning not stated Ischaemic stroke < 4 weeks since stroke onset (only 1 > 2 weeks)
Interventions	Treatment: ticlopidine 100 mg orally 8–12 hourly Control: no treatment Duration: up to 3 months (median 1 month)
Outcomes	Death Pulmonary embolism (symptomatic) Intracranial haemorrhage Extracranial haemorrhage
Funding source	No information available
Notes	Exclusions: unknown Follow‐up: 3 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Blocked randomisation code used.
Allocation concealment (selection bias)	Low risk	No concerns in allocation concealment.
Blinding of participants and personnel (performance bias) all outcomes	Unclear risk	Double‐blind trial but not stated explicitly who was blinded.
Blinding of outcome assessment (detection bias) all outcomes	Unclear risk	Double‐blind trial but unclear if outcome assessors were blinded.
Incomplete outcome data (attrition bias) all outcomes	Low risk	No concerns regarding missing outcome data.
Selective reporting (reporting bias)	Unclear risk	Prespecified analysis plan not included.
Other bias	Low risk	No sources of other bias identified.